Indirect pathway alloreactive CD4 T cells can provide help to induce cytotoxic CD8 T cells and are known to be the only cells that can provide help to alloreactive B cells (34C36). alloantigens through the direct, indirect or semi-direct pathway (Figure 1). The direct pathway of T cell recognition is unique to allogeneic transplantation, and … Continue reading Indirect pathway alloreactive CD4 T cells can provide help to induce cytotoxic CD8 T cells and are known to be the only cells that can provide help to alloreactive B cells (34C36)